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Winfried Meining

Publications

1. Schmid, C., Meining, W., Weinkauf, S., Bachmann, L., Ritz, H., Eberhardt, S., Gimbel, W., Werner, T., Lahm, H.-W., Nar, H. & Bacher, A. (1993). Studies on GTP Cyclohydrolase I of Escherichia coli. In Chemistry and Biology of Pteridines and Folates (Ayling, J. E., Nair, M. G. & Baugh, C. M., eds.), pp. 157-162. Plenum Press, New York. PDF

2. Meining, W., Nar, H., Schmid, C., Bacher, A., Bachmann, L. & Weinkauf, S. (1994). X-ray and electron microscopic studies on the crystal structure of GTP cyclohydrolase I from E. coli. Pteridines 5, 77. PDF

3. Meining, W., Schmid, C., Nar, H., Weinkauf, S. & Bacher, A. (1994). The crystal packing of GTP Cyclohydrolase I from Escherichia coli: a combined study by electron microscopy and x-ray analysis. In 13th International Congress on Electron Microscopy, ICEM 13 (Jouffrey, B. & Colliex, C., eds.), pp. 961-962. Les éditions des physique, Paris. PDF

4. Meining, W., Bacher, A., Weinkauf, S., Bachmann, L., Nar, H. & Huber, R. (1995). Determination of the crystal packing of cyclohydrolase I of Escherichia coli by a combined application of x-ray and freeze-etching electron microscopy techiques. In 8th International Conference on Pteridines and Related Biogenic Amines, Champfèr-St. Moritz. PDF

5. Nar, H., Huber, R., Meining, W., Schmid, C., Weinkauf, S. & Bacher, A. (1995). Atomic structure of GTP cyclohydrolase I. Structure 3, 459-466. HTML PDF

6. Meining, W., Bacher, A., Bachmann, L., Schmid, C., Weinkauf, S., Huber, R. & Nar, H. (1995). Elucidation of crystal packing by X-ray diffraction and freeze-etching electron microscopy. Studies on GTP cyclohydrolase I of Escherichia coli. J. Mol. Biol. 253, 208-218. HTML PDF

7. Nar, H., Huber, R., Auerbach, G., Fischer, M., Hösl, C., Ritz, H., Bracher, A., Meining, W., Eberhardt, S. & Bacher, A. (1995). Active site topology and reaction mechanism of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America 92(26), 12120-12125. HTML PDF

8. Nar, H., Huber, R., Meining, W., Bracher, A., Fischer, M., Hösl, C., Ritz, H., Schmid, C., Weinkauf, S. & Bacher, A. (1996). Structure and mechanism of GTP cyclohydrolase I of Escherichia coli. Biochemical Society Transactions 24(1), 37S. PDF

9. Meining, W., Tibbelin, G., Ladenstein, R., Eberhardt, S., Fischer, M. & Bacher, A. (1998). Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli. J. Struct. Biol. 121, 53-60. HTML PDF

10. Meining, W., Mörtl, S., Fischer, M., Cushman, M., Bacher, A. & Ladenstein, R. (2000). The atomic structure of pentameric Lumazine Synthase from Saccharomyces cerevisiae at 1.85 Å resolution reveals the binding mode of a phosphonate intermediate analogue. J. Mol. Biol. 299, 181-197. HTML PDF

11. Zhang, X., Meining, W., Fischer, M., Bacher, A. & Ladenstein, R. (2001). X-ray Structure Analysis and Crystallographic Refinement of Lumazine Synthase from the Hyperthermophile Aquifex aeolicus at 1.6 Å Resolution: Determinants of Thermostability revealed from Structural Comparisons. J. Mol. Biol. 306, 1099-1114. HTML PDF

12. Meining, W., Eberhardt, S., Bacher, A. & Ladenstein R. (2001). Crystallization and preliminary crystallographic analysis of the recombinant N-terminal domain of riboflavin synthase. Acta Cryst. D, 57, 1296-1299. HTML PDF

13. Braun, N., Meining, W., Hars, U., Fischer, M., Ladenstein, R., Huber, R., Bacher, A., Weinkauf, S., Bachmann, L. (2002). Formation of metal nanoclusters on specific surface sites of protein molecules. J. Mol. Biol. 321,341-353. HTML PDF

14. Meining, W., Zhang X., Fischer M., Bacher A., and Ladenstein R. (2002). On the enzymatic mechanism of lumazine synthase. Acta Cryst. (2002). A58 (Supplement), C107. PDF

15. Fischer M., Haase I., Kis K., Meining W., Ladenstein R., Huber R. and Bacher A. (2003). Enzyme catalysis via control of activation entropy. Site directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase. J. Mol. Biol. 326, 783-793. HTML PDF

16. Zhang X., Meining W., Cushman M., Haase I., Fischer M., Bacher A., and Ladenstein R. (2003). A structure-based Model of the Reaction Catalyzed by Lumazine Synthase from Aquifex aeolicus. J. Mol. Biol. 328, 167-182. HTML PDF

17. Meining W., Eberhardt S., Bacher A., and Ladenstein R. (2003). The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6 Å. J. Mol. Biol. 331, 1053-1063. HTML PDF

18. Ladenstein, R., W. Meining, Zhang, X. & Bacher, A. (2004). Metamorphosis of an Enzyme. Conformational Proteomics of Macromolecular Architecture: Approaching the Structure of Large Molecular Assemblies and Their Mechanisms of Action. H. Cheng and L. Hammar. Stockholm, World Scientific Pub. Co.: 198-221. PDF

19. Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R (2005). Crystal Structure of Lumazine Synthase from Mycobacterium tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors, Biochemistry, 44, 2746-2758. HTML PDF

20. Arnfors, L., Hansen, T., Meining, W., Schönheit, P. & Ladenstein, R. (2005). Expression, purification, crystallization and preliminary X-ray analysis of a nucleoside kinase from the hyperthermophile Methanocaldococcus jannaschii. Acta Crystallographica F61: 591-594. HTML PDF

21. Meining, W., Scheuring, J., Fischer, M. & Weinkauf, S. (2006). Cloning, purification, crystallization and preliminary crystallographic analysis of SecA from Enterococcus faecalis. Acta Crystallographica F62, 583-585. HTML PDF

22.Meining W. (2006). XtalBase - A comprehensive data management system for macromolecular crystallography. J. Appl. Cryst., 39, 759-766. HTML PDF

23. Zhang, X., Konarev, P., Svergun, D., Haase, I., Fischer, M., Bacher, A., Ladenstein, R. & Meining, W. (2006). Multiple assembly states of lumazine synthase - A model relating catalytic function and molecular assembly. J. Mol. Biol., 362, 753-770. HTML PDF

24. Arnfors, L., Hansen, Th., Schönheit, P., Ladenstein, R., & Meining, W. (2006). Crystal Structure of Methanocaldococcus jannaschii Nucleoside Kinase - An archaeal member of the ribokinase family. Acta Cryst., D62, 1085-1097. HTML PDF